We further evaluated the expression of AKT isoforms in different breast cancer cell lines and found that AKT1 and AKT2 were strongly expressed in the cells of Triple-negative cancer subtype, BT-549 and MDA-MB-231, compared to their corresponding expression in luminal MCF-7 and non-tumorigenic MCF-10A cells (Supplementary Figure 1A–1C). Here, AKT2 is linked to breast cancer.