At a gene level, PTPN11, NRAS, RASA2, SOS2, MAP2K1, and RAF1 were significantly associated with hypothyroidism, diastolic and systolic BP, birth weight, growth abnormality, subcutaneous adipose tissue, standing/sitting height ratio and body mass index (Fig 2B and Table 2). This evidence concerns the gene MAP2K1 and hypothyroidism.