TMEM116 and Autoimmunity: Although in consistent with the role of PTPN11 in thyroid function, cancer and autoimmunity [24–26], these variants are instead described as eQTLs with TMEM116, ALDH2 and MAPKAPK5-AS1 located up to 500kb upstream of PTPN11, suggesting that the associations observed with rs11066309, rs3741983 and rs11066322 could potentially also arise from associations with these other genes.