Among SNPs associated with multiple phenotypes, rs11066309 in PTPN11 displays a strong association with increased risk for hypothyroidism (ALT freq = 0.40; OR [95% CI]: 1.19; [1.16–1.21]; p = 6x10-59) along with five other phenotypes, including decreased body mass index (beta = -0.012, p = 1.13x10-06) and birth weight (beta = -0.020, p = 2.95x10-10) (Fig 1B and Table 1). This evidence concerns the gene PTPN11 and hypothyroidism.