ESR1 and breast carcinoma: Interestingly, similar effects of leptin on cellular ATP production were also observed in T47D cells, another estrogen receptor (ER)‐positive breast cancer line (Fig. 1C), but not in MDA‐MB‐231, triple‐negative breast cancer cells (Fig. 1D), suggesting a critical role of ER signaling in leptin‐stimulated ATP production.