After treatment of tumor bearing mice with leptin in the absence or presence of 3‐MA, we first examined the role of autophagy in leptin‐induced tumor growth in this model and found that leptin fueled breast tumor growth and this effect was significantly suppressed by cotreatment with the autophagy inhibitor 3‐MA, as determined by measurement of tumor growth, volume, and weight (Fig. S3A–D), confirming a critical contribution of autophagy induction to the tumor‐promoting effect of leptin in our experimental conditions. Here, LEP is linked to breast neoplasm.