Reducing the number of potentially mislabeled cases by focusing predominantly on lesions with genomic profile obtained from 2-[18F]FDG PET/CT-guided biopsies, applying partial volume effect and uptake time corrections, and using the ratio of maximum tumor to mean blood uptake in PET/CT scans, allowed for a highly statistically significant separation of colorectal adenocarcinoma liver lesions expressing KRAS missense mutations. This evidence concerns the gene KRAS and colorectal adenocarcinoma.