RIGI and viral infectious disease: Overall, the main bulk of identified genes are related to interferon induced pathways, such as CXCL10, a leukocyte chemoattractant during viral infection, IFIT1 and 2, two antiviral RNA-binding proteins [46] and OASL [80, 81]; a 2′-5′ oligoadenylate synthetase like gene which can bind double-stranded RNA and displays antiviral activity through mediating RIG-I activation [82, 83].