dIn our study, COX2-765, HIF-1α rs11549467, VDR rs2228570, TP53 rs9895829, CTLA-4 rs231775, MTHFR rs1801133, ABO rs49582, FTO rs9939609, CDKN2A/B rs2518719, XRCC4 rs2075685, XRCC1 rs25487, XPC rs2607775, MORC4 rs12837024, VEGF +405 rs2010963, and MTHFR rs1801133 were associated with greater risk of pancreatic cancer. This evidence concerns the gene MTHFR and familial pancreatic carcinoma.