Receiver operating characteristic (ROC) curves for serum survivin and fibulin-3 in discriminating lung cancer from malignant pleural mesothelioma revealed that the sensitivity, specificity, PPV, NPV and AUC for survivin (cut-off point >632 pg/ml) were 52.38%, 86.67%, 84.6%, 56.5%, and 0.603, respectively, while those values for fibulin-3 (cut-off point ≤9.16 pg/ml) were 100.0%, 93.3%, 95.5%, 100.0%, and 0.994, respectively (P<0.001) (Figure 3A,B). This evidence concerns the gene EFEMP1 and malignant pleural mesothelioma.