SYP and Parkinson disease: The literature also supports our finding that the NeuN+ presynaptic structures have strong labeling for synaptophysin and chromogranin A. The structures described as Lewy bodies by Nishimura et al. [46] contain both synaptophysin and chromogranin A, as we describe for our NeuN+ puncta/swellings, and they note that “Synaptic vesicles are thus presumably related to the formation of Lewy body.” And Wakabayashi et al. [73] found that Lewy bodies in several regions of the brain and in sympathetic ganglia of humans with Parkinson’s disease were primarily in axons, colocalizing with synaptophysin.