These structures partly colocalized with a number of proteins associated with AD, including Aβ, pTau, α-synuclein and chromogranin A. Labeling for a number of markers of AD was higher in the puncta of the DPP6-KO compared to WT, including Aβ, pTau, α-synuclein, and APP. This evidence concerns the gene DPP6 and Alzheimer disease.