S1PR2 and neoplasm: Furthermore, both endoscopic and microscopic examination revealed that S1PR2-deficient developed a significantly higher number of tumors compared to littermate’s WT animals (p < 0.001 and p = 0.028, respectively; Fig. 2e up panel and Fig. 2f) with increased serum levels of IL-17A, which it has been reported to promote tumor growth (Fig. S2f) [23].