S1PR2 and neoplasm: S1PR2 deficiency in Apcmin/+ at 21 weeks old led to a significant increase of total tumor load over the entire gastrointestinal tract compared with their littermates S1PR2+/+Apcmin/+ mice (p < 0.05) (Fig. 3a), which was well evident in the distal colon (p = 0.033) (Fig. 3b-c).