Besides, the histological analysis highlighted a marked increased number of high-grade adenomas (HGA) (1.3 ± 2.109 S1PR2−/− vs. 0.3 ± 0.483 S1PR2+/+ mice, p < 0.05) with a diameter between 0.3–0.4 mm and an increased number of carcinomas with diameter > 0.4 mm in S1PR2−/− compared to S1PR2+/+ mice (2.5 ± 3.6 S1PR2−/− vs. 1 ± 1.2 S1PR2+/+mice, p < 0.05) (Fig. 2e middle panels and Fig. 2g). The gene discussed is S1PR2; the disease is carcinoma.