S1PR2 and neoplasm: S1PR2 immunostaining enforced the evidence of its marked reduction in tumor lesions, where it was confined to the epithelial compartment, displaying a heterogeneous modulation varying from a low (intensity score 3) or moderate reduction (intensity score 1–2) to a complete loss (intensity score 0) of the receptor in CRC tissues compared to adjacent normal mucosa (Fig. 1e).