Based on a score of immunoreactivity that combines intensity and percentage of S1PR2 immunoreactivity (Supplementary Table 1), 25 (32,89%) out of 76 patients presented no reactivity (score 0); 23 (30,26%) displayed a low (score 1–2); 19 (25%) a medium (score 3–4) and only 9 (11,85%) a high (score 5–6) reaction comparable to healthy tissue (Fig. 1f), with no correlation with CRC stage (p = 0.4338) (Fig. 1g). The gene discussed is S1PR2; the disease is colorectal carcinoma.