For example, DNAJA3 and HSP90B1, which correlated with each other in 12 normal tissues, including breast (Rs = 0.50, false discovery rate [FDR] = 8.83 × 10−16) and lung (Rs = 0.49, FDR =1.69 × 10−13), had no significant co-expression in tumor tissues (breast invasive carcinoma [BRCA], Rs = 0.08, FDR = 0.14, and lung adenocarcinoma [LUAD], Rs = − 0.05, FDR = 0.55; Additional file 1: Fig. S1G). The gene discussed is DNAJA3; the disease is neoplasm.