For example, HSPB1 and DNAJC30 correlated with each other in eight cancer types, including BRCA (Rs = 0.39, FDR < 2.2 × 10−16) and LUAD (Rs = 0.47, FDR < 2.2 × 10−16), but had no significant or reduced co-expression in normal tissues, including breast (Rs = − 0.01, FDR = 1) and lung tissue (Rs = − 0.23, FDR = 4.6 × 10−5, Additional file 1: Fig. S1I). The gene discussed is HSPB1; the disease is cancer.