In this study, we comprehensively analyzed multi-omic data from The Cancer Genome Atlas (TCGA) [30], Cancer Cell Line Encyclopedia (CCLE) [31], Project Achilles [32], and Deep RNAi Interrogation of Viability Effects in Cancer (DRIVE) [33] and performed functional experiments to characterize HSPs across multiple cancer types to aid future rationalized development of improved HSP-targeted anti-cancer therapy. The gene discussed is HSP90B2P; the disease is cancer.