Mutations in some known ALL driver genes, such as NOTCH1 and FBXW7 (the E3-ligase charged with its recognition for ubiquitination [51]), are overrepresented among both pediatric and adult T-ALL in comparison with B-ALLs (χ2p = 1.05 × 10−16 and χ2p = 8.37 × 10−9, respectively). The gene discussed is NOTCH1; the disease is acute lymphoblastic leukemia.