We demonstrated here that circ-ERBIN promotes the proliferation, invasion, angiogenesis and metastasis of CRC by targeting miR-125a-5p and miR-138-5p and thus synergistically increases the expression of the eIF4E-binding protein 1 (4EBP-1), which subsequently enhances HIF-1α protein expression and activation of HIF-1α pathway. The gene discussed is ERBIN; the disease is colorectal carcinoma.