One particular Nrf2 agonist, sulforophane, has been shown to attenuate inflammation and disease in LPS-challenged mice [49] and in a chemically-induced model of diabetes [50] via similar mechanisms as we have observed in the current study, with ILA suppressing NF-kB activation and decreasing production of pro-inflammatory cytokines. The gene discussed is NFE2L2; the disease is diabetes mellitus.