No alterations in colorectal cancer/colorectal polyposis genes (APC, AXINS2, BMPR1A, CDH1, CHEK2, EPCAM, GREM1, MLH1, MSH2, MSH3, MSH6, MUTYH, NTHL1, PMS2, POLD1, POLE, POLE, PTEN, SMAD4, STK11, TP53) were identified. The gene discussed is POLE; the disease is colorectal cancer.