INS and diabetes mellitus: Previously, insulin-treated diabetics have been demonstrated to present more severe disease at a relatively young age.27 In this study, the median age for insulin users at revascularization was 72.4 (IQR: 64.0–79.5), which is significantly younger than in non-insulin diabetics and non-diabetics (NIT-DM 76.0, IQR: 67.9–83.6 versus non-DM 77.3, IQR: 68.5–83.7, p < 0.001).