KL and diabetic retinopathy: Klotho is a circulating anti-ageing hormone with anti-oxidative and anti-inflammatory properties that has demonstrated vascular protective effects in animal studies.1 Recent data suggests that low levels of circulating Klotho predicts increased risk of progression of cardiovascular and renal disease.2 The role of Klotho in predicting progression of diabetic retinopathy has not been studied and is currently unknown.