However, the Joint United Nations Programme on HIV/Acquired immunodeficiency syndrome (UNAIDS) estimated that approximately one out of three PLHIV presented for care with advanced HIV disease (AHD) [2], which was defined as an initial CD4 cell count below 200 cells/μL or an AIDS‐defining event regardless of CD4 cell count according to the European consensus definition [3]. The gene discussed is CD4; the disease is mitochondrial DNA depletion syndrome 4a.