The molecular mechanism linking extra centrosomes to p53 activation involves the PIDDosome, a multi‐protein complex which is formed by PIDD1 and RAIDD to activate caspase‐2 (Tinel & Tschopp, 2004; Fava et al, 2017), a protease with documented tumor‐suppressive capacity (Ho et al, 2009; Ribe et al, 2012; Parsons et al, 2013; Puccini et al, 2013a) as well as regulatory roles in liver metabolism (Wilson et al, 2015; Kim et al, 2018). This evidence concerns the gene CRADD and neoplasm.