ERBB2 and neoplasm: As such, the PIDDosome should exert tumor‐suppressive functions that may explain observations of increased rates of tumor formation in mice lacking caspase‐2, challenged by oncogenic drivers such as MYC or ERBB2, or concomitant ATM loss (Ho et al, 2009; Manzl et al, 2012; Parsons et al, 2013; Puccini et al, 2013b).