Equally noteworthy here, an increased occurrence of CNVs upon Casp2 deletion or transcriptional repression, as noted in transformed mouse B cells or human colorectal carcinoma, respectively (Dawar et al, 2016; López‐García et al, 2017), was neither found in the healthy liver (Sladky et al, 2020) nor in chemically induced HCC (Fig 4). The gene discussed is CASP2; the disease is colorectal carcinoma.