These results shed more light into recent works where megalin was shown to be an extremely important receptor for cell proliferation and survival, e.g. in melanoma cells, in which sustained megalin expression was crucial for cell maintenance and proliferation (mainly overexpressed), being a target for therapy (Andersen et al., 2015); in non-Hodgkin-lymphoma, in which LRP2 has increased expression mainly in neurons (Pedersen et al., 2010). This evidence concerns the gene LRP2 and non-Hodgkin lymphoma.