These results shed more light into recent works where megalin was shown to be an extremely important receptor for cell proliferation and survival, e.g. in melanoma cells, in which sustained megalin expression was crucial for cell maintenance and proliferation (mainly overexpressed), being a target for therapy (Andersen et al., 2015); in non-Hodgkin-lymphoma, in which LRP2 has increased expression mainly in neurons (Pedersen et al., 2010). Here, LRP2 is linked to melanoma.