Within this group sit the cryopyrin-associated periodic syndromes (CAPS) which comprise three diseases of worsening severity: familial cold autoinflammatory syndrome (FCAS), Muckle–Wells syndrome (MWS) and neonatal-onset multisystem inflammatory disease or chronic infantile neurologic cutaneous articular syndrome (NOMID/CINCA).22 This evidence concerns the gene NLRP3 and familial cold autoinflammatory syndrome.