Then, we set a threshold using the mean control levels plus 2 SD for abnormal titers; the positive rate of anti-Tyro3 IgG in SLE, RA, and pSS was 24/70 (34.3%), 3/24 (12.5%), and 4/21 (19.0%), respectively, indicating that Tyro3 receptor antibody might be an important biomarker and play a role in the pathogenesis of SLE. Here, TYRO3 is linked to systemic lupus erythematosus.