The significant hallmarks of AD are (i) the shrinkage of the hippocampus and cortex in the brain, (ii) senile plaques mainly composed of Aβ aggregates, (iii) neurofibrillary tangles (NFT) containing the aggregates of hyperphosphorylated tau (ptau), (iv) miscompartmentalization of metal ions, and (v) oxidative stress [7–9]. The gene discussed is MAPT; the disease is Alzheimer disease.