MAPT and Alzheimer disease: Alzheimer's disease (AD) and Parkinson's disease (PD) are the most common cases of ND which could be caused by multiple factors, including (i) the accumulation of misfolded amyloidogenic proteins such as amyloid-β (Aβ), tau, and α-synuclein (α-syn), (ii) cholinergic deficit, (iii) metal ion dyshomeostasis, and (iv) oxidative stress induced by overproduced reactive oxygen species (ROS) [2, 3].