CYP19A1 and Pulmonary arterial hypertension associated with portal hypertension: Recently, Al-Naamani et al. showed that in PoPH patients, the risk allele rs7175922 in CYP19A1 was associated with significantly higher levels of estradiol, urinary 2-hydroxyestrogen/16-α-hydroxyestrone (2-OHE/16α-OHE1), plasma levels of dehydroepiandrosterone-sulfate and plasma levels of 16-α-hydroxyestradiol (16α-OHE2) compared to the patients with liver disease but no PoPH (51).