Taubenberger et al. (2016) investigated the involvement of specific cell adhesion domains on interactions between tumor cells organized in spheroids and capillaries. For this purpose, an integrin binding domain present in fibronectin and vitronectin (RGD), a laminin-111 derived adhesion peptide (IKVAV), and an integrin binding domain present in collagen I (GFOGER) were conjugated to PEG hydrogel. Tumor spheroid formation and co-inclusion with EC and MSC in these functionalized hydrogels were performed as in Bray et al. (2015). This evidence concerns the gene VTN and neoplasm.