SQSTM1 and cancer: Thus, the connection of oxidative stress to cancer promotion and the abnormal accumulation of p62 in several breast (Thompson et al., 2003; Li S. S. et al., 2017) and other cancers (Kitamura et al., 2006; Inoue et al., 2012; Saito et al., 2016) may in part explain the tumor suppressive effects of autophagy.