Indeed, disruption of this interaction using a small molecule, Tat-Beclin 1, in mice bearing BT-474-VH2 xenografts resulted in increased autophagy induction and reduced tumor progression as effectively as treatment with the tyrosine kinase inhibitor lapatinib (Vega-Rubin-de-Celis et al., 2018). The gene discussed is BECN1; the disease is neoplasm.