SQSTM1 and cancer: Autophagy may also protect against cancer via suppression of oxidative stress via modulation of nuclear factor erythroid 2-related factor 2 (Nfe2l2/Nrf2)/kelch-like ECH-associated protein 1 (Keap1) and SQSTM1/p62 pathway (Komatsu et al., 2010; Jiang et al., 2015).