SH3GLB1 and neoplasm: Similarly, mice with either a monoallelic deletion for autophagy and Beclin1 regulator 1 (Ambra1) or a biallelic deletion for SH3 Domain Containing GRB2 Like, Endophilin B1 (SH3GLB1, aka Bif-1) revealed higher rates of spontaneous tumor incidence (Cianfanelli et al., 2015).