Based on its characteristics of expression, TRAF5 is closely related to many immune-related diseases, such as systemic lupus erythematosus (SLE), inflammatory bowel disease (IBD), and the infection of classical swine fever virus (CSFV) (Wang et al., 2015; Shang et al., 2016; Lv H. et al., 2018). Here, TRAF5 is linked to systemic lupus erythematosus.