The overactivation of the NF-κB pathway can result in the inflammatory diseases, cardiovascular diseases, autoimmune diseases and cancers; therefore, the NF-κB pathway is tightly regulated to ensure the physiological homeostasis of body systems (Barnes and Karin, 1997; Wong et al., 1999; Kis et al., 2003; DiDonato et al., 2012). This evidence concerns the gene NFKB1 and autoimmune disease.