Thyme quinone (a natural compound isolated from Nigella sativa) can induce the release of superoxide anion and hydrogen peroxide in ABC cells which promoted IκBα dephosphorylation, arrested NF-κB p65 nuclear translocation, and finally inhibited the NF-κB pathway-mediated ABC cell survival pathway (Hussain et al., 2013). The gene discussed is NFKB1; the disease is aneurysmal bone cyst.