More recently, PLGA nanospheres-encapsulated fenofibrate showed full biocompatibility and attenuation of both, VEGF expression and vascular tissue disruption for up to 60 weeks after IVT injection in a rat W-AMD model, a diabetic retinopathy rat model and a very low-density lipoprotein receptor knockout (Vldlr–/–) mouse model (Qiu et al., 2019). The gene discussed is VEGFA; the disease is age-related macular degeneration.