Our finding of suppressed IL-8 by sEVs from the TVV+TV infection may have clinical significance for the extracellular parasite adaptation since IL-8 is involved in the recruitment of neutrophils (Shaio et al., 1995)—the immune cells primarily responsible for clearance of TV parasites (Mercer et al., 2018; Bhakta et al., 2020). Here, CXCL8 is linked to infection.