As shown in Figure 3A, sEVs from the vaginal infection with both TVV+ strains suppressed IL-8 production by the PBMCs in comparison to sEVs derived from uninfected vaginal cells (p = 0.0296 and p = 0.0015 for 347V+ and UR1 infection, respectively). The gene discussed is CXCL8; the disease is infective vaginitis.