ESRP1 and neoplasm: In our series we found that ESRP1 expression in tumor positively correlated with NE markers, such as AURKA and EZH2, and negatively with the EMT markers ZEB1 and AXL. ESRP1 mediates alternative splicing of a panel of transcripts involved in maintaining epithelial features, becoming then an important EMT regulator (45).