MAPKAPK2 and neoplasm: Besides, studies have found that MAPKAP Kinase 2 (MK2), which mediates the synthesis of proinflammatory cytokines, promotes TAMs to the M2 macrophage phenotype and promotes angiogenesis into tumor development, while chemical inhibitors of MK2 in macrophages inhibit M2 polarization and M2 macrophage-induced angiogenesis (168).