The loss of cytoplasmic phospholipase A2 (cPLA2) in macrophages can reduce the secretion of IL-6 by tumor cells and prevent the progression and metastasis of lung cancer (177), which indicates that cPLA2 plays a key role in tumor progression, and targeting the expression of cPLA2 in TAMs can provide new therapeutic strategies for the clinical treatment of tumors. Here, IL6 is linked to neoplasm.