CLOCK and glioblastoma: In the GBM study of glioblastoma, it is found that the high expression of CLOCK in GSCs could maintain the stemness of GSCs, which promotes the expression of chemokine OLFML3 as a transcription factor, thus accelerating the infiltration of microglia into GBM, but it did not affect the recruitment of macrophages, and the mechanism remains unclear (123).