The loss of cytoplasmic phospholipase A2 (cPLA2) in macrophages can reduce the secretion of IL-6 by tumor cells and prevent the progression and metastasis of lung cancer (177), which indicates that cPLA2 plays a key role in tumor progression, and targeting the expression of cPLA2 in TAMs can provide new therapeutic strategies for the clinical treatment of tumors. Here, IL6 is linked to lung cancer.