Furthermore, IL-8 secreted by macrophages, in turn, activates the protein kinase C (PKC) signaling pathway of colon cancer cells, which enhances the production of CSF1 in colon cancer cells (10), indicating that the interaction between tumor cells and TAMs forms a vicious cycle, thus promoting the recruitment of macrophages in tumor tissues. The gene discussed is PRRT2; the disease is malignant colon neoplasm.