STAT3 and neoplasm: High expression of transcriptional factor Sox2 in breast cancer cells activates nuclear factor of activated T cells (NFAT), signal transducer and activator of transcription 3, (STAT3), and NF-κB signalings to secrete chemokines CCL3 and intercellular adhesion molecule-1 (ICAM-1), which recruit TAMs into the tumor microenvironment and promote tumor metastasis (26).