RBPJ and neoplasm: It is worth noting that although the Notch signaling promotes the differentiation of monocyte into TAMs, the Notch signaling can promote the pro-inflammatory polarization of differentiated TAMs toward M1, which suggests that targeting to enhance the expression of RBP-J of TAMs and enhancing Notch signaling to promote the M1 polarization of TAMs may have potential for tumor treatment.