Activation of TLR4 on M2-polarized TAMs stimulates an increase in the IL-10, which promotes the EMT of pancreatic cancer cells, specifically in increased the morphology of fibroblasts, up-regulated the expression of mesenchymal markers Vimentin and Snail, and increased the proliferation, migration, and proteolytic activities of MMP 2 and MMP9 in pancreatic cancer cells. This evidence concerns the gene TLR4 and familial pancreatic carcinoma.