STAT6 and neoplasm: Furthermore, glycocalyx-mimicking nanoparticles (GNPs) can be specifically internalized by TAMs via lectin receptors, resulting in to up-regulation IL-12 and down-regulation of IL-10, arginase 1, and CCL22 expression, reversing TAMs to an anti-tumor phenotype, in which the process is associated with suppressing STAT6 and activating NF-κB phosphorylation.