Indeed, IL-6 secreted by TAM acts on glioma cells and promotes 3-phosphoinositide dependent protein kinase 1 (PDPK1) mediated phosphoglycerate kinase 1 (PGK1) phosphorylation (T243), which changed the affinity between PGK1 and the substrate, promoting the activity of the glycolysis direction of PGK1, and the aerobic glycolysis, cell proliferation and tumor growth of glioma cells (97). Here, PDPK1 is linked to central nervous system cancer.