Utilizing the online bioinformatics tool GEPIA (http://gepia.cancer-pku.cn/detail.php) (16), we also found that patients with HCC with increased METTL3 and IGF2BP2 mRNA levels had worse overall survival (OS) (Figure 1B) (the group cutoff was set as quartile [cutoff-high (%) was 75% and cutoff-low (%) was 25%)]. This evidence concerns the gene IGF2BP2 and hepatocellular carcinoma.