Further, SFRP1 expression was elevated in response to miR-1260b downregulation in LAD tissues, and we found an association between miR-1260b expression and progression-free survival in LAD patients, suggesting that miR-1260b and SFRP1 might function as important regulators in the chemosensitivity and EMT phenotype of LAD cells. Here, SFRP1 is linked to leukocyte adhesion deficiency.