TP53 and neoplasm: Gene set enrichment analysis analysis of the potential mechanism by which prognosis-related genes influence PDAC revealed that in the high SKA1 expression group, there was significant enrichment for cell cycle-related biological processes (GO: cell division, cell cycle checkpoint, and cell cycle phase transition, Figures 8A–C) and tumor-related signaling pathways (KEGG: cell cycle, P53 signaling pathway, and DNA replication, Figures 8D–I).