Table 1 shows the relationship between CTC-WBC clusters and clinicopathological characteristics of HCC. Statistical analysis showed that CTC-WBC clusters were significantly correlated with tumor size (P = 0.001), tumor number (P = 0.005), portal vein tumor thrombus (P = 0.026), BCLC stage (P < 0.001), AFP level (P = 0.002), and total number of CTCs (P < 0.001). The gene discussed is AFP; the disease is hepatocellular carcinoma.