NR1H3 and Familial prostate cancer: Among LNCaP, 22RV1, PC3, and DU145 prostate cancer cell lines and one immortalized cell line (RWPE-1) tested, mRNA and protein levels of LXR-α were lower in prostate cancer cell lines (Figures 1D,E), whereas mRNA and protein levels of LXR-β were similar in all cell lines (Figures 1D,E).