Our conclusion is supported by the following lines of evidence: (1) Among 59 tumor TMA samples, the high EGFR staining group is largely associated with the low staining group of LXR-α, and vice versa; (2) Among prostate cell lines tested, there is a general tendency of inversed protein levels between EGFR and FOXO3A. Here, NR1H3 is linked to neoplasm.