This system has a classical arm and renin/ACE1/angiotensin II/angiotensin II type 1 receptor axis which has physiologic and pathologic roles in diseases of the kidney, blood vessels, heart, and brain and the ACE2/angiotensin (1–7)/mitochondrial assembly receptor (MasR) axis, which has been identified as a negative regulator of angiotensin II [15]. This evidence concerns the gene AGT and urogenital neoplasm.