SYP and appendicitis: All neuroimmunoendocrine mediators (synaptophysine, enolase, mast cell tryptase, PGP-9.5 and protein S100) had greater expression only in group 1 of morphologically normal appendices of patients with clinical manifestations of acute appendicitis and were probably responsible for nausea, vomiting, abdominal pain and diarrhea (Fig. 1).