ATG5 and amyotrophic lateral sclerosis: For example, neonatal lethality in Atg5 knockout mice is rescued after restoration of neuronal-specific expression of ATG5 [104]; meanwhile, autophagy activation in the mouse brain protects against mDAN loss mediated by oxidative stress [105], and autophagy induction using a neuronal pharmacophore in amyotrophic lateral sclerosis (ALS) and Huntington's mouse models promotes neuronal survival [106].