VEGFA and cancer: VEGFA is frequently upregulated in human cancers, and its important role in angiogenesis led to a development of therapies targeting VEGF and VEGF receptor [37], for example, bevacizumab, a monoclonal antibody that interrupts the interaction between VEGFA and its receptors (VEGFR1 and VEGFR2) and has already been used in a clinical setting [38].