Overall, CALCA, CDK6, MDM2, NRXN1, SOCS3, VEGFA, SMAD4, NCAM1, and miR-127-5p were considered to be potential genetic diagnosis biomarkers for MI, which could help to distinguish MI from angina patients from the perspective of genetics and improve accurate diagnosis and therapies of MI. The gene discussed is MDM2; the disease is myocardial infarction.