EGFR and cancer: At the promotion stage of cancer, a wide variety of mechanisms could be involved in the flavonoids positive effects on carcinogenic cells which include inactivation of epidermal growth factor receptor (EGFR), inhibition of thymidylate synthase, inhibition of thioredoxin reductase, acting on glucose-regulated protein 78, changing of the vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1 (HIF-1) expression (7-10).