Pathogenesis of obesity involves a combination of excessive caloric intake, sedentary lifestyle, and the effects of multiple hormones and adipokines that involve body weight and appetite control such as leptin, adiponectin, proopiomelanocortin, prohormone convertase 1, melanocortin receptor 3 (MC3R), and melanocortin receptor 4 (MC4R) [2]. The gene discussed is LEP; the disease is Obesity.