Nevertheless, our results suggest a more accurate gating of B-cell populations using AG&I vs MG, since using the AG&I approach, B-cell alterations were only detected in the KMT2A-deficient patients, which are expected to have a CVID-like phenotype (24), but not in the IRAK4-deficient and MBL-deficient patients for whom no lymphoid deviations are usually expected (2, 9). This evidence concerns the gene KMT2A and common variable immunodeficiency.