The IRAK4 deficiency sample and MBL deficiency sample (both conditions for which no lymphoid deviations are usually expected) also showed clinically relevant differences for the unswitched MBC/PC subpopulation, with abnormal values for the MG approach (below p5 for the IRAK4 deficiency and above p95 for the MBL deficiency), but normal absolute counts for all B-cell subpopulations when analyzed with the AG&I tool. Here, MBL2 is linked to hyperinsulinemic hypoglycemia, familial, 4.