Decrease MDSCs through the induction of ApoE and potentiate activation of cytotoxic lymphocytes (43).Oxysterols impairs DC migration through the inhibition of CCR7 (44).Activation of LXRα in macrophages stimulatesphagocytosis of dying cancer cells (45).LXR upregulates the expression of theNKG2D ligands MICA and MICB in MM and improved NK cell cytotoxicity (46). The gene discussed is APOE; the disease is cancer.