SPHK2 and neoplasm: Induction of cholesterol efflux and reduction of its uptake with consequent reduced tumor cell proliferation and survival (38–39).Reduced expression/activity of cell-cycle regulators (SPK2) (40), higher expression of cell-cycle inhibitors (p21, p27) and decreased phospho-RB protein levels (41, 42).Delayed progression of androgen-dependent tumors towards androgen independence (41, 42).