TLR2, TLR3, and TLR4 were strongly expressed on the SGECs of patients with Sjögren syndrome, and TLR2 signaling induces the production of IL-23/IL-17 via IL-6 and signal transducer and activator of transcription (STAT) in the NF-κB pathway in Sjögren syndrome (84, 85). This evidence concerns the gene TLR4 and Sjogren syndrome.