SPDL1 and neoplasm: In this study, changes in sPD-L1 levels, IDH-1 mutational status and tumor location were independent prognostic factors (P = 0.003, HR = 0.019, 95% CI: 0.001–0.268; P = 0.011, HR = 0.029, 95% CI: 0.002–0.448; P = 0.002, HR = 26.302, 95% CI: 3.239–213.550) (Table 2).