While non-opsonized HIV-1 poorly replicates in DCs, covalently linked iC3b fragments on the HIV-1 surface were illustrated to significantly enhance de novo (cis) infection of CR3/CR4-expressing DC subsets (LCs, dermal DCs, blood BDCA1+ DCs) and CR3-expressing monocytes and macrophages (7–10, 46, 66–71). Here, CRIPTOP4 is linked to infection.