Via secretion of mediators such as IL-21, IL-4, and IL-13, TFH cells orchestrate B cells to differentiate to plasma cells producing allergen-specific IgE, which can bind to surface FcεRIs on mast cells and basophils, where crosslinking upon re-exposure to the allergen will result in a type-I hypersensitivity reaction culminating in the clinical manifestations of food allergy (33) (Figure 1). This evidence concerns the gene IGHE and food allergy.