While mainly TH2 cytokines are reduced during OIT, one study of 29 patients (1–16 years) with peanut allergy observed that patients treated with OIT had higher levels of IL-10, IL-5, IFN-γ, and TNF-α from peanut-stimulated PBMCs compared with controls (104). The gene discussed is IL5; the disease is peanut allergic reaction.