SIRT1 and optic neuritis: A study that examined potential neuroprotective effects in optic neuritis by SRT647 and SRT501, activators of SIRT1, an enzyme involved in cellular stress resistance and survival, demonstrated that SIRT1 activation prevents RGC loss in optic neuritis even in the presence of active inflammation, suggesting that their neuroprotective effects will be additive to other immunomodulatory treatments (69).